[Frontiers in Bioscience 3, d684-700, July 2, 1998]

	[Frontiers in Bioscience 3, d684-700, July 2, 1998] Reprints PubMed CAVEAT LECTOR
	REGULATION OF THE EXTRACELLULAR LIGAND BINDING ACTIVITY OF INTEGRINS Catherine Fernandez , Katherine Clark, Louise Burrows, Neil R. Schofield, Martin J. Humphries School of Biological Sciences, University of Manchester, Room 2.205 Stopford Building, Oxford Road, Manchester M13 9PT Received 5/27/98 Accepted 6/8/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Integrin structure 3.1. Alpha subunit A-domain 3.2. Putative beta subunit A-domain 3.3. Alpha subunit N-terminal repeats 4. Ligand binding sites in integrins 4.1. Sites in alpha subunits 4.2. Sites in beta subunits 5. Use of divalent cations and monoclonal antibodies to probe conformational changes in integrin-ligand binding 5.1. Role of divalent cations 5.2. Conformation-dependent epitopes 6. Regulation of ligand binding mediated by inside-out signalling 6.1. Motifs within cytoplasmic domains 6.2. Inside-out regulation by cytoplasmic proteins 6.3. Inside-out regulation by membrane-anchored proteins 6.4. Intracellular signalling pathways 7. Perspective 8. References 9. Entire manuscript Key words: Integrin, Structure, Ligand Binding Sites, Conformational Changes, Divalent Cations, Monoclonal Antibodies, Inside-Out Signalling Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d684-700, July 2, 1998]
Reprints
PubMed
CAVEAT LECTOR

REGULATION OF THE EXTRACELLULAR LIGAND BINDING ACTIVITY OF INTEGRINS

Catherine Fernandez , Katherine Clark, Louise Burrows, Neil R. Schofield, Martin J. Humphries

School of Biological Sciences, University of Manchester, Room 2.205 Stopford Building, Oxford Road, Manchester M13 9PT

Received 5/27/98 Accepted 6/8/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Integrin structure: 3.1. Alpha subunit A-domain
3.2. Putative beta subunit A-domain
3.3. Alpha subunit N-terminal repeats
4. Ligand binding sites in integrins: 4.1. Sites in alpha subunits
4.2. Sites in beta subunits
5. Use of divalent cations and monoclonal antibodies to probe conformational changes in integrin-ligand binding: 5.1. Role of divalent cations
5.2. Conformation-dependent epitopes
6. Regulation of ligand binding mediated by inside-out signalling: 6.1. Motifs within cytoplasmic domains
6.2. Inside-out regulation by cytoplasmic proteins
6.3. Inside-out regulation by membrane-anchored proteins
6.4. Intracellular signalling pathways
7. Perspective
8. References
9. Entire manuscript

Key words: Integrin, Structure, Ligand Binding Sites, Conformational Changes, Divalent Cations, Monoclonal Antibodies, Inside-Out Signalling

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.